Cian O’Donnell


I’m a computational neuroscience postdoc at the Computational Neurobiology Laboratory in the Salk Institute, La Jolla, California.


My full CV is here as webpage and pdf.

You can find my Google Scholar profile here.


History:

  1. 2012-present. Computational neuroscience postdoc with Terry Sejnowski at the Computational Neurobiology Laboratory in the Salk Institute, La Jolla, California.

  2. 2011. Neuroscience postdoc with Matt Nolan, University of Edinburgh.

  3. 2007-2011. PhD in Computational Neuroscience with Mark van Rossum and Matt Nolan in the Neuroinformatics Doctoral Training Centre, University of Edinburgh.

  4. 2006-2007. MSc in Neuroinformatics, School of Informatics, University of Edinburgh.

  1. Research interests

  2. I’m interested in neural computation. I use computational modeling to study neurons and circuits.

  3. More specifically:

  4. Fragile-X Syndrome and Autism. Analysing cortical network dynamics from disease mouse models.

  5. Synaptic plasticity and long-term memory. Protein synthesis, synaptic strength dynamics, STDP.

  6. Neural noise. The impact of neural noise and variability on computation.

  7. Synaptic integration. How single neurons transform complex spatiotemporal inputs into a spike output.

  8. Entorhinal cortical grid cells and their role in the hippocampal circuit.


Publications

  1. O’Donnell C and van Rossum MCW.
    Spontaneous action potentials and neural coding in unmyelinated axons.
    Neural Computation 27(4), 801-18 (2015)
    pdf here.

  2. O’Donnell C and van Rossum MCW.
    Systematic analysis of the contributions of stochastic voltage gated channels to neuronal noise.
    Frontiers in Computational Neuroscience 8, 105 (2014)
    pdf here.

  3. O’Donnell C and Sejnowski TJ.
    Selective memory generalization by spatial patterning of protein synthesis.
    Neuron 82, 398-412 (2014).
    pdf here.

  4. O’Donnell C and Nolan MF.
    Stochastic ion channel gating and probabilistic computation in dendritic neurons (book chapter).
    The Computing Dendrite: from structure to function (2014). Ed. M Remme, B Torben-Nielsen, and H Cuntz. Springer Series in Computational Neuroscience
    pdf here.

  5. O’Donnell C, Nolan MF, van Rossum MCW.
    Dendritic spine dynamics regulate the long-term stability of synaptic plasticity.
    J Neurosci 31(45), 16142-16156 (2011).
    pdf here.

  6. O’Donnell C and Nolan MF.
    Tuning of synaptic responses: an organizing principle for optimization of neural circuits.
    Trends Neurosci 34(2), 51-60 (2011).
    pdf here.

  7. Cannon RC*, O’Donnell C*, Nolan MF.
    Stochastic ion channel gating in dendritic neurons: morphology dependence and probabilistic synaptic activation of dendritic spikes.
    PLoS Comput Biol 12;6(8) e1000886 (2010).
    pdf here.
    * Equal contribution

  8. Garden DLF, Dodson PD, O’Donnell C, White MD, Nolan MF.
    Tuning of synaptic integration by entorhinal cortical neurons to the organization of grid fields.
    Neuron 60(5), 875-889 (2008).
    pdf here.

Manuscripts submitted or in preparation

  1. O’Donnell C, Goncalves JT, Portera-Cailliau C and Sejnowski TJ.
    Altered dimensionality of neocortical activity in Fragile-X mice.
    (submitted)

  2. O’Donnell C, Foer M and Sejnowski TJ.
    A two-step neural model for memory generalization during sleep.
    (in preparation)

  3. O’Donnell C, Nolan MF and van Rossum MCW.
    Stochastic ion channel gating as a mechanism for spontaneous firing in thin axons in neuropathic pain conditions.
    (in preparation)

Poster presentations

  1. Altered dimensionality of neural population activity in Fragile-X mice from in vivo 2-photon Ca2+ imaging. O’Donnell C and Sejnowski, TJ. WABC annual symposium. Salk Institute, 10/2014

  2. Generalization of memories by dendritic protein sharing. O’Donnell C and Sejnowski, TJ. HHMI Investigators meeting. Janelia Research Campus, MD, 09/2014

  3. Generalization of memories by dendritic protein sharing. O’Donnell C and Sejnowski, TJ. COSYNE. Salt Lake City, UT, 02/2014

  4. Selective memory storage by spatial patterning of protein synthesis. O’Donnell C and Sejnowski, TJ. Society for Neuroscience, San Diego, CA, 11/2013

  5. Computational analysis of neocortical dynamics in Fragile-X model mice. O’Donnell C and Sejnowski, TJ. FRAXA Investigators meeting, Southbridge, MA, 09/2013

  6. Generalization of memories by dendritic protein sharing. O’Donnell C and Sejnowski, TJ. Dendrites Gordon Research Conference. Les Diablerets, Switzerland, 05/2013

  7. The computational impact of local dendritic protein translation on synaptic plasticity and memory. O’Donnell C and Sejnowski, TJ. Salk/Fondation Ipsen/Nature Symposium on Biological Complexity: Molecular Biology of Psychiatric Disorders. La Jolla, CA 01/2013

  8. The computational impact of local dendritic protein translation on synaptic plasticity and memory. O’Donnell C and Sejnowski, TJ. Society for Neuroscience, New Orleans, 10/2012

  9. Dendritic spine dynamics and the stability of synaptic plasticity. O’Donnell C, Nolan MF and
    van Rossum MCW. Sloan-Swartz Centers Annual Meeting, La Jolla, CA 06/2012

  10. Dendritic spine dynamics regulate the long-term stability of synaptic plasticity. O’Donnell C, Nolan MF, van Rossum MCW. INCF Neuroinformatics Congress, Boston, USA 09/2011

  11. Dendritic spine plasticity can stabilise synaptic weights. O’Donnell C, Nolan MF, van Rossum MCW. Cosyne, Salt Lake City, USA 02/2010.

  12. Stochastic action potentials in axons: a possible role in neuropathic pain. O’Donnell C, Nolan MF, van Rossum MCW. Society for Neuroscience, Chicago 10/2009.

  13. Dendritic spines as devices for synaptic metaplasticity. O’Donnell C, van Rossum MCW. Scottish Neuroscience Group, St Andrews, UK 07/2009.

  14. Dendritic spines as devices for synaptic metaplasticity. O’Donnell C, van Rossum MCW. Dendrites Gordon Research Conference, Lucca, Italy 05/2009.

  15. Spontaneous spiking from ion channel noise in cable axons. O’Donnell C, van Rossum MCW. Mathematical Neuroscience, Edinburgh 03/2009.

  16. The impact of stochastic ion channel activity depends on neuronal morphology. O’Donnell C, van Rossum MCW, Cannon RC, Nolan MF. PENS-Hertie Winter School in Neural Circuits, Obergurgl, Austria 01/2009.

  17. The impact of stochastic ion channel activity depends on neuronal morphology. O’Donnell C, van Rossum MCW, Cannon RC, Nolan MF. INCF Neuroinformatics, Stockholm 09/2008.

  18. PSICS: a new tool for simulation of stochastic ion channels in neurons with complex dendritic and axonal morphologies. Nolan MF, O’Donnell C, Cannon RC. FENS, Geneva 07/2008.

  19. Stochastic ion channels in dendritic spines. O’Donnell C, Nolan MF, van Rossum MCW. Mathematical Neuroscience, Edinburgh 03/2008.

  1. CNL-S

  2. Salk Institute

  3. 10010 North Torrey Pines Road

  4. La Jolla, CA 92037

  5. USA